| 03 Mar 13 | r01        | CD Chivas USACD Chivas USA | 0 - 3 | Columbus CrewColumbus Crew |
| 10 Mar 13 | r01        | Vancouver WhitecapsVancouver Whi | 2 - 1 | Columbus CrewColumbus Crew |
| 16 Mar 13 | r01        | Columbus CrewColumbus Crew | 1 - 1 | San Jose EarthquakesSan Jose Eart |
| 23 Mar 13 | r01        | DC UnitedDC United | 1 - 2 | Columbus CrewColumbus Crew |
| 06 Apr 13 | r01        | Columbus CrewColumbus Crew | 1 - 1 | Philadelphia UnionPhiladelphia |
| 14 Apr 13 | r01        | Montreal ImpactMontreal Impa | 1 - 1 | Columbus CrewColumbus Crew |
| 21 Apr 13 | r01        | Chicago FireChicago Fire | 1 - 0 | Columbus CrewColumbus Crew |
| 28 Apr 13 | r01        | Columbus CrewColumbus Crew | 3 - 0 | DC UnitedDC United |
| 04 May 13 | r01        | Columbus CrewColumbus Crew | 0 - 1 | New York Red BullsNew York Red |
| 11 May 13 | r01        | Columbus CrewColumbus Crew | 0 - 2 | Colorado RapidsColorado Rapi |
| 18 May 13 | r01        | Toronto FCToronto FC | 0 - 1 | Columbus CrewColumbus Crew |
| 26 May 13 | r01        | New York Red BullsNew York Red | 2 - 2 | Columbus CrewColumbus Crew |
| 01 Jun 13 | r01        | Columbus CrewColumbus Crew | 1 - 1 | Houston DynamoHouston Dynam |
| 05 Jun 13 | r01        | Philadelphia UnionPhiladelphia | 3 - 0 | Columbus CrewColumbus Crew |
| 15 Jun 13 | r01        | Columbus CrewColumbus Crew | 2 - 0 | Montreal ImpactMontreal Impa |
| 23 Jun 13 | r01        | Columbus CrewColumbus Crew | 1 - 2 | Chicago FireChicago Fire |
| 30 Jun 13 | r01        | Sporting Kansas CitySporting Kans | 3 - 2 | Columbus CrewColumbus Crew |
| 05 Jul 13 | r01        | L.A. GalaxyL.A. Galaxy | 2 - 1 | Columbus CrewColumbus Crew |
| 07 Jul 13 | r01        | Columbus CrewColumbus Crew | 1 - 0 | Portland TimbersPortland Timb |
| 20 Jul 13 | r01        | Columbus CrewColumbus Crew | 0 - 2 | New England Rev.New England R |
| 27 Jul 13 | r01        | Toronto FCToronto FC | 2 - 1 | Columbus CrewColumbus Crew |
| 04 Aug 13 | r01        | Houston DynamoHouston Dynam | 3 - 1 | Columbus CrewColumbus Crew |
| 10 Aug 13 | r01        | Columbus CrewColumbus Crew | 2 - 0 | New York Red BullsNew York Red |
| 17 Aug 13 | r01        | Columbus CrewColumbus Crew | 2 - 0 | Toronto FCToronto FC |
| 25 Aug 13 | r01        | Real Salt LakeReal Salt Lak | 4 - 0 | Columbus CrewColumbus Crew |
| 31 Aug 13 | r01        | Columbus CrewColumbus Crew | 0 - 1 | Seattle Sounders FCSeattle Sound |
| 04 Sep 13 | r01        | Columbus CrewColumbus Crew | 2 - 0 | Houston DynamoHouston Dynam |
| 08 Sep 13 | r01        | Sporting Kansas CitySporting Kans | 3 - 0 | Columbus CrewColumbus Crew |
| 14 Sep 13 | r01        | Montreal ImpactMontreal Impa | 1 - 2 | Columbus CrewColumbus Crew |
| 21 Sep 13 | r01        | Columbus CrewColumbus Crew | 3 - 0 | Chicago FireChicago Fire |
| 30 Sep 13 | r01        | FC DallasFC Dallas | 2 - 4 | Columbus CrewColumbus Crew |
| 05 Oct 13 | r01        | Columbus CrewColumbus Crew | 0 - 1 | Sporting Kansas CitySporting Kans |
| 19 Oct 13 | r01        | New England Rev.New England R | 3 - 2 | Columbus CrewColumbus Crew |
| 27 Oct 13 | r01        | Columbus CrewColumbus Crew | 0 - 1 | New England Rev.New England R |