| 16 Aug 80 | r00        | OldhamOldham | 1 - 0 | QPRQPR |
| 19 Aug 80 | r00        | QPRQPR | 4 - 0 | Bristol RoversBristol Rover |
| 23 Aug 80 | r00        | QPRQPR | 0 - 0 | SwanseaSwansea |
| 30 Aug 80 | r00        | ChelseaChelsea | 1 - 1 | QPRQPR |
| 06 Sep 80 | r00        | Notts CountyNotts County | 2 - 1 | QPRQPR |
| 13 Sep 80 | r00        | QPRQPR | 1 - 2 | NewcastleNewcastle |
| 20 Sep 80 | r00        | Sheffield WedsSheffield Wed | 1 - 0 | QPRQPR |
| 27 Sep 80 | r00        | QPRQPR | 4 - 0 | Bristol CityBristol City |
| 04 Oct 80 | r00        | BlackburnBlackburn | 2 - 1 | QPRQPR |
| 07 Oct 80 | r00        | QPRQPR | 0 - 0 | Leyton OrientLeyton Orient |
| 11 Oct 80 | r00        | QPRQPR | 3 - 1 | BoltonBolton |
| 18 Oct 80 | r00        | DerbyDerby | 3 - 3 | QPRQPR |
| 22 Oct 80 | r00        | CardiffCardiff | 1 - 0 | QPRQPR |
| 25 Oct 80 | r00        | QPRQPR | 0 - 1 | WrexhamWrexham |
| 01 Nov 80 | r00        | GrimsbyGrimsby | 0 - 0 | QPRQPR |
| 08 Nov 80 | r00        | QPRQPR | 3 - 2 | LutonLuton |
| 11 Nov 80 | r00        | Bristol RoversBristol Rover | 1 - 2 | QPRQPR |
| 15 Nov 80 | r00        | QPRQPR | 2 - 0 | OldhamOldham |
| 22 Nov 80 | r00        | PrestonPreston | 3 - 2 | QPRQPR |
| 29 Nov 80 | r00        | QPRQPR | 0 - 0 | ShrewsburyShrewsbury |
| 06 Dec 80 | r00        | Cambridge UnitedCambridge Uni | 1 - 0 | QPRQPR |
| 19 Dec 80 | r00        | BoltonBolton | 1 - 2 | QPRQPR |
| 26 Dec 80 | r00        | QPRQPR | 3 - 0 | West HamWest Ham |
| 27 Dec 80 | r00        | WatfordWatford | 1 - 1 | QPRQPR |
| 10 Jan 81 | r00        | QPRQPR | 1 - 1 | PrestonPreston |
| 17 Jan 81 | r00        | QPRQPR | 1 - 0 | ChelseaChelsea |
| 31 Jan 81 | r00        | SwanseaSwansea | 1 - 2 | QPRQPR |
| 03 Feb 81 | r00        | QPRQPR | 2 - 0 | CardiffCardiff |
| 07 Feb 81 | r00        | NewcastleNewcastle | 1 - 0 | QPRQPR |
| 14 Feb 81 | r00        | QPRQPR | 1 - 1 | Notts CountyNotts County |
| 21 Feb 81 | r00        | Bristol CityBristol City | 0 - 1 | QPRQPR |
| 28 Feb 81 | r00        | QPRQPR | 1 - 2 | Sheffield WedsSheffield Wed |
| 07 Mar 81 | r00        | QPRQPR | 1 - 1 | BlackburnBlackburn |
| 21 Mar 81 | r00        | QPRQPR | 3 - 1 | DerbyDerby |
| 28 Mar 81 | r00        | WrexhamWrexham | 1 - 1 | QPRQPR |
| 31 Mar 81 | r00        | Leyton OrientLeyton Orient | 4 - 0 | QPRQPR |
| 04 Apr 81 | r00        | QPRQPR | 1 - 0 | GrimsbyGrimsby |
| 11 Apr 81 | r00        | LutonLuton | 3 - 0 | QPRQPR |
| 18 Apr 81 | r00        | QPRQPR | 0 - 0 | WatfordWatford |
| 21 Apr 81 | r00        | West HamWest Ham | 3 - 0 | QPRQPR |
| 25 Apr 81 | r00        | QPRQPR | 5 - 0 | Cambridge UnitedCambridge Uni |
| 02 May 81 | r00        | ShrewsburyShrewsbury | 3 - 3 | QPRQPR |